The Gene Damage Index (GDI) Server

Estimate the GDI for a list of genes. Genes with high damage prediction are unlikely to be disease-causing.

Link to the main GDI project webpage

Disease Type: All diseases Mendelian (general model) Mendelian (autosomal dominant) Mendelian (autosomal recessive) Cancer (general model) Cancer (autosomal dominant) Cancer (autosomal recessive) PID (general model) PID (autosomal dominant) PID (autosomal recessive) Autism

In addition, display selective pressure (McDonald-Kreitman neutrality index)

Type in genes separated with space, tab or comma in one or multiple rows

Citation

Itan Y, Shang L, Boisson B, Patin E, Bolze A, Moncada-Vélez M, Scott E, Ciancanelli M, Lafaille F, Markle J, Martinez-Barricarte R, De Jong SJ, Kong X-F, Nitschke P, Belkadi A, Bustamante J, Puel A, Boisson-Dupuis S, Stenson PD, Gleeson JG, Cooper DN, Quintana-Murci L, Claverie J-M, Zhang S-Y, Abel L and Casanova J-L. The human gene damage index as a gene-level approach to prioritize exome variants.

Contact

In case of problems or questions, please e-mail Yuval Itan at: yitan@rockefeller.edu

The Rockefeller University

St. Giles Laboratory of Human Genetics of Infectious Disease