The Gene Damage Index (GDI) Server

Estimate the GDI for a list of genes. Genes with high damage prediction are unlikely to be disease-causing.

Link to the main GDI project webpage

Disease Type:

In addition, display selective pressure (McDonald-Kreitman neutrality index)

Type in genes separated with space, tab or comma in one or multiple rows


Itan Y, Shang L, Boisson B, Patin E, Bolze A, Moncada-VĂ©lez M, Scott E, Ciancanelli M, Lafaille F, Markle J, Martinez-Barricarte R, De Jong SJ, Kong X-F, Nitschke P, Belkadi A, Bustamante J, Puel A, Boisson-Dupuis S, Stenson PD, Gleeson JG, Cooper DN, Quintana-Murci L, Claverie J-M, Zhang S-Y, Abel L and Casanova J-L. The human gene damage index as a gene-level approach to prioritize exome variants.


In case of problems or questions, please e-mail Yuval Itan at:

The Rockefeller University

St. Giles Laboratory of Human Genetics of Infectious Disease